International Journal of

Ophthalmology and Clinical ResearchISSN: 2378-346X

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 Open Access DOI:10.23937/2378-346X/1410084

The Effect of Prostaglandin Analogues on Central Corneal Thickness

Umut Duygu Uzunel

Article Type: Research Article | First Published: March 31, 2018

Prostaglandin (PG) analogues are being widely used to reduce Intraocular Pressure (IOP) in glaucoma patients. These drugs reduce IOP by stimulation of aqueous humor drainage primarily through the uveoscleral outflow pathway but significant effects on trabecular outflow facility also have been reported. The suggested mechanism of IOP reduction involves aqueous humor outflow enhancement through the uveoscleral pathway accompanied by collagen degradation in the ciliary body. This collagen degradati...

 Open Access DOI:10.23937/2378-346X/1410083

Intraocular Pressure-Lowering Effect of Ripasudil Hydrochloride Hydrate and Reasons for Discontinuation of Use in Clinical Practice

Kana Kawara, Akiyasu Kanamori, Sotaro Mori, Yukako Inoue, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada and Makoto Nakamura

Article Type: Research Article | First Published: January 26, 2018

The median pre- and post-application IOP at 1, 3, and 6 months was 19.0, 17.5, 17.0, and 16.0 mmHg, respectively. IOP was significantly reduced after ripasudil application at all time points (P < 0.00001, the mixed effect model). The pre-application IOP and glaucoma type were associated with the IOP-lowering effect of ripasudil. Twenty-seven and 8 patients discontinued the application because of unsatisfactory IOP reduction and intolerable side effects, respectively....

Volume 5
Issue 1