International Journal of

Immunology and ImmunotherapyISSN: 2378-3672

Archive

 Open Access DOI:10.23937/2378-3672/1410002

Cockroach Allergy, Respiratory Allergic Diseases and Its Immunotherapy

Oner Ozdemir

Article Type: Review Article | First Published: December 31, 2014

Cockroach allergen-derived proteases play a direct role on airway epithelial as well as dendritic cells thru activation of the protease activated receptor (PAR)-2. Cockroach-derived proteases lead to an increased penetration of cockroach allergen thru disturbing airway epithelial integrity, which can activate innate immune cells (e.g., dendritic cells) via binding to Toll-like receptor or C-type lectin receptors. The activated dendritic cells promote the adaptive immune system cells to a Th2 cel...

 Open Access DOI:10.23937/2378-3672/1410001

Polarization of Human THP-1 Macrophages: Link between Adenosine Receptors, Inflammation and Lipid Accumulation

Michael J. Littlefild, Isaac Teboul, Iryna Voloshyna and Allison B. Reiss

Article Type: Research Article | First Published: December 08, 2014

Rationale: Macrophages are key players in inflammation and atherosclerosis. They express surface receptors of different subtypes for the endogenous autocoid adenosine. Macrophages within atherosclerotic lesions attain two clear-cut functional phenotypes M1 (pro-inflammatory) and M2 (immunosuppressive). This study examines the relative expression of adenosine receptors and proteins involved in cholesterol transport in THP-1 human macrophages upon differentiation into M1 and M2 subtypes....

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