Journal of

Dermatology Research and TherapyISSN: 2469-5750


 Open Access DOI:10.23937/2469-5750/1510037

A Single-Site, Investigator Initiated Open-Label Trial of H.P. Acthar® Gel (Repository Corticotropin Injection) an Adrenocorticotropic Hormone (ACTH) Analogue in Subjects with Moderately to Severely Active Psoriatic Arthritis (PsA)

Justus J Fiechtner, Tresa Montroy and Joshua June

Article Type: Original Article | First Published: October 26, 2016

Although several therapeutic agents are available for psoriatic arthritis (PsA), each has limitations. Acthar® Gel (repository corticotropin injection) is FDA-approved for treatment of acute episodes or exacerbation of PsA, but no clinical trials have investigated it for those uses. This 28-week, prospective, single-center, open-label trial included subjects with moderately to severely active PsA. The primary outcome measure was ACR20 at Week 12....

 Open Access DOI:10.23937/2469-5750/1510036

Topical Treatment of Cutaneous Leishmaniasis: Wound Reduction in Mice Using N-Methyl Glucamine from PVP and Nano Clay Membranes

Maria Jose Alves de Oliveira, Regina Maia, Lucia Almeida Braz, Ademar Benevolo Lugao, Valdir Sabbaga Amato and Duclerc Fernandes Parra

Article Type: Original Article | First Published: October 24, 2016

Biomaterials comprise a scientific field where synthetic materials are developed for pertinent biological functions, yielding a wide diversity of new products. Although widely employed, they still require improvement for therapeutic purposes. The objective of this study was to develop poly (N-2-vinyl-pyrrolidone) (PVP), poly (vinyl alcohol) (PVAl), clay, and N-methyl glucamine hydrogels for the treatment of cutaneous leishmaniasis. The characterization techniques used were tumescence, energy-dis...

 Open Access DOI:10.23937/2469-5750/1510035

The Role of the Mast Cell in Skin Aging

Yang-lin Hua, Wei Gao, Hong-ying Li and Jian Tang

Article Type: Mini Review | First Published: October 14, 2016

Skin is the external organ of human body that provides protection against environmental stress. Direct and indirect damage causes skin aging. Scientists have been struggling to explore the mechanisms of skin aging and to think of ways to delay this course. The role of mast cell in regulating skin aging has attracted much attention recently. The granules of mast cell contain a great diversity of highly toxic compounds and active mediators. Degranulation of mast cell in papillary dermis may lead t...

 Open Access DOI:10.23937/2469-5750/1510034

Cutaneous Manifestations in Patients with Systemic Lupus Erythematosus: Data from a Multiethnic Latin American Cohort (GLADEL)

Maria J Haye Salinas, Veronica Saurit, Alejandro Alvarellos, Francisco Caeiro, Daniel Wojdyla, Cristina Drenkard, Guillermo J Pons-Estel, Luis J Catoggio, Judith Sarano, Eduardo Ferreira Borba, Emilia Sato, Sergio Jacobelli, Luis A Ramirez, Marlene Guibert -Toledano, Virginia Pascual-Ramos, Mario H Cardiel, Maria I Segami, Isaac Abadi, Graciela S Alarcon, Bernardo A Pons-Estel and Latin American Study Group on Lupus (GLADEL)

Article Type: Original Research | First Published: October 12, 2016

SLE patients from 34 centers in nine Latin American countries with a recent diagnosis (≤ 2 years) were studied. Socioeconomic-demographic characteristics and clinical features according to the presence of cutaneous manifestations were examined by univariable and multivariable logistic regression analyses. Their predictive value for the occurrence of other clinical manifestations was also examined....

 Open Access DOI:10.23937/2469-5750/1510033

A Fatal Infection due to Gordonia Terrae

Jeong Rae Yoo, Miyeon Kim, Keun Hwa Lee, Seung Jin Yoo, Chang lim Hyun, Jonghwan Bae, Sang Taek Heo and Yong-Geun Park

Article Type: Case Report | First Published: October 05, 2016

A 53-year-old man with a history of poliomyelitis underwent left total hip arthroplasty in December 2011. His past medical history was not significant except the medical conditions described disease. The patient had developed a sore on right perianal area since March 2013 (Figure 1A), and infected sore lesion was extended to abscess on a right buttock abscess one year later, it was managed with incision and drainage in right buttock abscess since November 2014. ...

Volume 2
Issue 5