Fluorescence in Situ Hybridization (FISH) Copy Number Abnormalities at 6p (RREB1), 6q (MYB), and 11q (CCND1) Reliably Distinguish Metastatic Versus Benign Melanocytic Lesions
Zaid Hindi, Michael Sidiropoulos, Ayman Al Habeeb, Danny Ghazarian, Niloufar Hosseini and Kenneth J. Craddock
Article Type: Original Research | First Published: February 29, 2016
Multicolour FISH was performed using a commercially available probeset (Abbott Laboratories, Abbott Park, IL), on formalin-fixed, paraffin-embedded tissue samples from 40 tumours: 20 benign melanocytic nevi, and 20 metastatic melanomas within lymph nodes, as determined by histologic assessment. Fluorescent signals for each probe were enumerated by 2 observers in 30 cells each per lesion....
A Rare Case of Erosive Pustular Dermatosis Involving the Upper Limb
Paul Ting-Yuan Cheng, Lissa Elaine Judd and Agneta Carol Fullarton
Article Type: Review Article | First Published: February 29, 2016
Erosive pustular dermatosis (EPD) is a cutaneous inflammatory condition, characterized by chronically non-healing lesions with sterile pustules and hyperkeratotic crusted erosions. Although rare, severe cases have been referred by dermatologists to plastic surgeons for management. The aim of this paper was to describe the presentation and management of extensive EPD as well as a review of current literature on this rare condition....
Targeting Myostatin Signaling in Skin Healing
Christoph Wallner, Marcus Lehnhardt and Bjorn Behr
Article Type: Short Review | First Published: February 17, 2016
Myostatin is a protein well described for its role in decelerating muscle anabolism. Most studies targeting the Myostatin pathway were performed in muscle wasting diseases. Recent studies unveil a potential approach to interfere with the Myostatin pathway to facilitate wound healing. We therefore reviewed the present literature for aiming the Myostatin pathway as a potential treatment option in impaired skin healing. The inhibition of Myostatin may facilitate wound healing through different ways...
Knowledge and Behaviors toward the Sun and Skin Cancer: A Study of Hispanics in New York and Florida
Kate V. Viola, Kameron S. Rezzadeh, Daniel G. Federman, Christine J. Mathew, Shasa Hu, Andrea D. Maderal, Steven R. Cohen and Robert S. Kirsner
Article Type: Research Article | First Published: January 16, 2016
Over 3 million skin cancers are diagnosed in the United States each year. While the incidence of skin cancer is lower in patients of Hispanic descent, a recent report by the Center for Disease Control (CDC) found melanoma incidence rates to be significantly higher in Hispanic women under the age of 50 as compared to Hispanic men; Hispanics had the highest incidence of acral lentigenous melanoma among all races and ethnicities....
Rapid Improvement of Hidradenitis Suppurativa Following Sleeve Gastrectomy
Jong-Seob Park, Ji-Sun Hong and Sang-Moon Han
Article Type: Case Report | First Published: January 16, 2016
Severe obesity is commonly associated with dermatologic disorders such as intertrigo, psoriasis and hidradenitis suppurativa (HS). HS is a chronic inflammatory skin disease characterized by clusters of nodules, cysts, and abscesses that commonly affects hair bearing areas such as axilla, groin and perianal regions. Treatments of HS are complicated and vary depending on presentation and severity of the disease. We report here, the case of a 36-year-old female who showed rapid improvement of long-...