International Journal of

Diabetes and Clinical ResearchISSN: 2377-3634

Archive

 Open Access DOI:10.23937/2377-3634/1410017

Effect of Alogliptin, a DPP-4 Inhibitor, on Markers of Lipid Metabolism in Type 2 Diabetic Patients

Yuzuru Kishitani, Hideyuki Okuda, Daisuke Kinoshita, Kanyun Hata and Toshihiko Kawasaki

Article Type: Research Article | First Published: December 31, 2014

Background: DPP-4 inhibitor has been shown to improve not only blood glucose levels but also dyslipidemia, but the effect remains controversial. Further, there are few reports regarding the influence on Apo B, Apo A-1 and Apo B/Apo A-1 in alogliptin. Objective: Using the alogliptin, we focused on Apo B and Apo A-1, in addition to LDL-C, HDL-C and TG, and investigated the effect of alogliptin on markers predicting cardiovascular events, such as Apo B/Apo A-1 and LDL-C/Apo B....

 Open Access DOI:10.23937/2377-3634/1410016

Correlations of OSA Severity and Carotid Intima-Media Thickness in Patients with Type 2 Diabetes

Jiang Xiao-zhen, Xi Feng, Chen Rui-Hua, Jiang Quan and Zou Yu-Feng

Article Type: Review Article | First Published: December 29, 2014

Aim: To determine whether carotid intima-media thickness (C-IMT) was elevated in diabetic patients with Obstructive Sleep Apnea (OSA), and correlations of OSA severity with IMT and other clinical characteristics. Materials and methods: The study subjects were composed of 36 diabetic patients with OSA (group A), and 34 patients without OSA (group B). In both groups, blood lipids, fasting blood glucose, glycated hemoglobin, Epworth Sleepiness Scale, C-IMT and carotid resistance index (C-RI) were a...

 Open Access DOI:10.23937/2377-3634/1410015

Involvement of Telmisartan on the Protective Effects Mediated by the Peroxisome Proliferator-Activated Receptor-γ Pathway in Mice

Chenghu Huang, Li Yuan and Shuyi Cao

Article Type: Review Article | First Published: December 08, 2014

Aims: The aim of this study is to further elaborate the improving effects of telmisartan on insulin resistance, beta-cell dysfunction and islet inflammation in a PPAR-γ signaling-dependent manner. Methods: The mRNA levels of renin-angiotensin system components were detected. We compared the effects of telmisartan and telmisartan combined with GW9662 (a PPAR-γ antagonist) in mice fed a high-fat diet or isolated non-diabetic mouse islets. Immunoflorescence or real-time PCR was used to de...

 Open Access DOI:10.23937/2377-3634/1410014

Ethnicity and Type 2 Diabetes in Pacific Island Adults in New Zealand

Ljiljana M Jowitt

Article Type: Review Article | First Published: December 02, 2014

The aim of this review was to present ethnic characteristics of type 2 diabetes in Pacific Island adults in New Zealand. International databases including PubMed and Google scholar were consulted in a search using the terms 'Pacific Island populations', 'New Zealand', 'ethnicity', 'obesity', 'metabolic syndrome', 'type 2diabetes', 'food security, and their combinations, as well as the websites of the World Health Organization, International Diabetes Federation, and the Ministry of Health New Zea...

 Open Access DOI:10.23937/2377-3634/1410013

The Relative Contribution of Ethnicity, Overweight and Gestational Diabetes Severity to Postpartum Abnormal Glucose Tolerance

Beatriz Barquiel, Lucrecia Herranz, Javier Riveiro, Natalia Hillman, Noemi Gonzalez, Ma Angeles Burgos and Luis F Pallardo

Article Type: Research Article | First Published: December 01, 2014

Aim: To analyze the influence of ethnicity, Body Mass Index (BMI) and gestational diabetes (GDM) severity on abnormal glucose metabolism at the early postpartum. Methods: Glucose tolerance (WHO criteria) was evaluated at 3-9 months after delivery in a group of 71 GDM women (NDDG criteria) coming from Latin America, 43 from Africa and 14 from Asia or Pacific Islands. Their glucose tolerance was compared to 1,948 European control women by prepregnancy and postpartum BMI and by GDM severity. The ef...

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