International Journal of

Cancer and Clinical ResearchISSN: 2378-3419


 Open Access DOI:10.23937/2378-3419/1410146

Chemotherapy Safe Handling through Educating Nurses: A Pre-Experimental Study

Rakhi Mishra, MScN, Bhawana, MScN and Ajay Kushwaha, MScN

Article Type: Original Article | First Published: February 25, 2021

Chemotherapy is a proven prodigy for the treatment of carcinoma but it can possess certain deleterious effects on the healthcare professionals while on constant exposure. Being frontline workers, nursing officers continuously come in contact with these chemotherapeutic agents. Hence, it is of paramount importance that nurses working in oncology unit have adequate knowledge and skill regarding safe handling of chemotherapeutic drugs....

 Open Access DOI:10.23937/2378-3419/1410145

Effect of Low Frequency Electrical Current on the Biophysical and Molecular Properties of Cancer Cells

Amit Sengupta, Sanjay Gupta, Asmita Sharda, Hemant S and Arvind Ingle

Article Type: Research Article | First Published: February 25, 2021

Different cells and tissues are known to exhibit varied electromagnetic, electrical and molecular properties. During the repair process, cancer cells as well as normal proliferating cells have higher transmembrane potential than healthy cells. Since the dielectric properties are frequency dependent, applying varying frequencies of current can alter the transmembrane ionic flux of any conductive cell. This, in turn, can generate heat via the joule effect. Thus, it might be possible to alter the t...

 Open Access DOI:10.23937/2378-3419/1410144

CXCR4 Antagonist AMD3100 (Plerixafor) Modulates Immune Responses in the Tumor Microenvironment

Ziyao Liu, Jingzhe Wang and Huabiao Chen

Article Type: Mini Review | First Published: January 30, 2021

AMD3100 (Plerixafor), a specific antagonist of CXCR4, is the most potent small molecule non-peptide inhibitor to CXCR4/CXCL12 axis. The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) expressed in a variety of tumor cells play an important role in regulating tumor biological behavior. The tumor microenvironment (TME) is the environment around a tumor, comprising blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix which are involved in tumor growth, i...

Volume 8
Issue 1