Chemotherapy Safe Handling through Educating Nurses: A Pre-Experimental Study
Rakhi Mishra, MScN, Bhawana, MScN and Ajay Kushwaha, MScN
Article Type: Original Article | First Published: February 25, 2021
Chemotherapy is a proven prodigy for the treatment of carcinoma but it can possess certain deleterious effects on the healthcare professionals while on constant exposure. Being frontline workers, nursing officers continuously come in contact with these chemotherapeutic agents. Hence, it is of paramount importance that nurses working in oncology unit have adequate knowledge and skill regarding safe handling of chemotherapeutic drugs....
Effect of Low Frequency Electrical Current on the Biophysical and Molecular Properties of Cancer Cells
Amit Sengupta, Sanjay Gupta, Asmita Sharda, Hemant S and Arvind Ingle
Article Type: Research Article | First Published: February 25, 2021
Different cells and tissues are known to exhibit varied electromagnetic, electrical and molecular properties. During the repair process, cancer cells as well as normal proliferating cells have higher transmembrane potential than healthy cells. Since the dielectric properties are frequency dependent, applying varying frequencies of current can alter the transmembrane ionic flux of any conductive cell. This, in turn, can generate heat via the joule effect. Thus, it might be possible to alter the t...
CXCR4 Antagonist AMD3100 (Plerixafor) Modulates Immune Responses in the Tumor Microenvironment
Ziyao Liu, Jingzhe Wang and Huabiao Chen
Article Type: Mini Review | First Published: January 30, 2021
AMD3100 (Plerixafor), a specific antagonist of CXCR4, is the most potent small molecule non-peptide inhibitor to CXCR4/CXCL12 axis. The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) expressed in a variety of tumor cells play an important role in regulating tumor biological behavior. The tumor microenvironment (TME) is the environment around a tumor, comprising blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix which are involved in tumor growth, i...