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International Journal of

Cancer and Clinical ResearchISSN: 2378-3419

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 Open Access DOI:10.23937/2378-3419/1410089

Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue HER2-Positive Breast Cancer Patients

Seiichi Mokuyasu and Yasuhiro Suzuki

Article Type: Original Article | First Published: November 18, 2017

Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently evaluated histopathologically. Immunohistochemistry and fluorescence in situ hybridization require invasive enucleation of the tumor tissue and may be affected by heterogeneity....

 Open Access DOI:10.23937/2378-3419/1410088

Ipilimumab Activity in Advanced Uveal Melanoma: A Pooled Analysis

Muhammad A Khattak and Elin Gray

Article Type: Original Research | First Published: November 18, 2017

Uveal Melanoma is a rare tumour that displays different clinical behavior and molecular features compared with cutaneous melanoma. It is generally resistant to systemic therapy and there is no current standard effective therapy to treat patients with advanced disease....

 Open Access DOI:10.23937/2378-3419/1410087

Immune Paralysis and the Spontaneous Remission of Cancer

BH Behzad Niakan

Article Type: short review article | First Published: November 16, 2017

Once a malignant growth grows past a certain size immune tolerance rather than immune sensitization occurs possibly due to the slow tumor growth. As the malignant grows larger some branches of the immune system (adoptive immunity) become protective of it, while other branches of the immune system oppose its growth....

 Open Access DOI:10.23937/2378-3419/1410086

The Omission of Axillary Lymph Node Dissection in Sentinel Node-Positive Breast Cancer Patients Requires Careful Consideration

Hiroko Nogi, Takashi Kazama, Rei Mimoto, Yoshimi Imawari, Makiko Kamio, Hisashi Shioya, Yasuo Toriumi, Ken Uchida, Masafumi Suzuki and Hiroshi Takeyama

Article Type: Research Article | First Published: October 30, 2017

Sentinel Node Biopsy (SNB) is used to accurately assess axillary lymph node status in patients with node-negative breast cancer. The purpose of this study was to assess the association between non-sentinel node (SN) metastasis and clinicopathological findings in patients with one or two SN-positive breast cancer....

 Open Access DOI:10.23937/2378-3419/1410085

Assessing Response to Chemoradiotherapy on 18F-FDG PET Images in Non-Small Cell Lung Cancer using New Approaches of Histogram and Gray Level Co-Occurrence Matrix

Changdong Ma, Judong Luo, Yong Hou and Changsheng Ma

Article Type: Research Article | First Published: October 28, 2017

Twelve patients with newly diagnosed NSCLC and treated with combined Chemoradiotherapy (CRT) were involved in this study. We analyzed the percentage variation of gray value in every gray level or on the whole using histogram analysis algorithm which represents global intensity distribution....

 Open Access DOI:10.23937/2378-3419/1410084

The Utilization of Partial Orchiectomy in Treating Small Testicular Tumors in the United States

Shaheen Alanee, Joseph Clemons, Bradley Holland, Max Nutt and Danuta Dynda

Article Type: Research Article | First Published: October 18, 2017

There is increasing evidence supporting the feasibility of Partial Orchiectomy (PO) as a treatment for small testicular tumors. However, the prevalence of this practice is still unknown. We used the Surveillance, Epidemiology, and End results (SEER) registry to characterize national practice patterns for surgical management of patients with testicular tumors ≤ 2 cm in size, and we examined factors that determined performing PO in such patients....

 Open Access DOI:10.23937/2378-3419/1410083

Physiological Effort in Submaximal Fitness Tests Predicts Weight Loss in Overweight and Obese Men with Prostate Cancer in a Weight Loss Trial

Andrew D Frugé, John A Dasher, David Bryan, Soroush Rais-Bahrami, Wendy Demark-Wahnefried and Gary R Hunter

Article Type: Research Article | First Published: October 16, 2017

Obesity and weight gain after the diagnosis of prostate cancer are associated with an increased risk of prostate cancer recurrence and mortality; individualized plans to help prostate cancer survivors maintain or lose weight may be beneficial for recurrence risk reduction....

 Open Access DOI:10.23937/2378-3419/1410082

Radiolabeled APIs for the Conduct of Human ADME Studies of Oncology Compounds

Yuexian Li, Mihaela Plesescu and Shimoga R Prakash

Article Type: Research Article | First Published: August 30, 2017

Human ADME (Absorption, Distribution, Metabolism, and Excretion) studies of new chemical entities are an important part of the drug development process. These studies are normally performed by using a radioactive tracer (C-14 or H-3) blended with a therapeutic dose of non-radioactive drug in about four to six subjects. The radiolabeled API (Active Pharmaceutical Ingredient) is utilized to evaluate the recovery and track the metabolic fate and physiological disposition of the drug....

 Open Access DOI:10.23937/2378-3419/1410081

Bioactive Peptides from Legumes as Anticancer Therapeutic Agents

Gonzalez-Montoya Marcela, Cano-Sampedro Eden and Mora-Escobedo Rosalva

Article Type: Review Article | First Published: July 19, 2017

Food proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. Legume seed proteins have been widely studied to produce peptides (protein fragments) with a diversity of biological activities....

Volume 4
Issue 2