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Case Report  |   Volume 3, Issue 1

Incidental Paget's Disease of the Nipple in a Prophylactic Skin-Sparing Mastectomy for BRCA1 Mutation: Implications for Increased Use of Prophylactic Nipple Sparing Mastectomy

Esther Dubrovsky, Farayan Jalalabi, Aysegul Sahin and Dalliah M Black
Abstract

Prophylactic skin-sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) have become suitable options for breast cancer prevention in appropriate patients with hereditary risk of breast cancer. Prophylactic total mastectomy (TM) provides approximately 90% to 95%- risk reduction in patients with BRCA1 and BRCA 2 mutations. Initially, bilateral TM was recommended because of the concern for an increased breast cancer risk from remaining residual breast tissue.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1044

Case Report  |   Volume 3, Issue 1

Metastatic Pancreatic Adenocarcinoma to a Lymph Node with Diffuse Large B Cell Lymphoma: A Case Report and Review of the Literature

Xiao Huang, Kazunori Kanehira, Fadi Habib and Bo Xu
Abstract

Metastatic carcinoma to a lymph node with high grade lymphoma is very rare, particularly when high grade lymphoma is the first time diagnosis. Here we report a case where metastatic pancreatic ductal adenocarcinoma was found in a retroperitoneal lymph node with diffuse large B cell lymphoma (DLBCL). Histologically, the metastatic adenocarcinoma is located mainly in the subcapsular region.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1045

Research Article  |   Volume 3, Issue 1

Developing Pathway Collection for Personalized Anti-cancer Therapy

Luminita Castillos and Anton Yuryev
Abstract

We describe methodology for developing personalized anti-cancer drug therapy using pathway analysis. We successfully applied this methodology to treat several cancer patients that were terminally diagnosed by standard of care criteria at the hospital. Our approach consists of profiling patient tumor using gene expression microarray and calculating pathways responsible for the differential expression between tumor and normal control tissue.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1043

Case Report  |   Volume 3, Issue 1

Breast Cancer in Surgical Site: Unusual Presentation of an Ectopic Milk Line Malignancy

Zsolt Varga, Miklos Torok, Eva Sebo, Judit Toth and Dezso Toth
Abstract

A 56-year old woman with history of laparoscopic cholecystectomy was referred to outpatient clinic 3 years after the operation with a non-healing reddish lump in the surgical scar. The lesion was situated at the site of the right subcostal port, in the medioclavicular line, below the ribcage. Local excision was performed and histological evaluation revealed poorly differentiated adenocarcinoma, which was thought to be metastatic. After multiple recurrences, appearance of an axillary lymph node metastasis and persistent search without any sign of other tumor, it had to be considered as a possibility, if there is no distant source of metastases, rather than a the lesion is a primary cancer.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1042

Original Research  |   Volume 3, Issue 1

The Usefulness of Nutritional Index CONUT for Risk Assessment and Prognosis after Pancreaticoduodenectomy

Shinichi Sekine, Takuya Nagata, Tomoyuki Okumura, Shunsuke Kawai, Katsuhisa Hirano, Takeshi Miwa, Makoto Moriyama, Hirofumi Kojima, Isaya Hashimoto, Kazuto Shibuya, Shozo Hojo, Isaku Yoshioka, Koshi Matsui, Shigeaki Sawada and Kazuhiro Tsukada
Abstract

Pancreaticoduodenectomy (PD) is a highly invasive surgery. Therefore, assessment of pre-operative nutritional status may contribute to the postoperative course. Patients (n = 116) who had undergone PD were included in this study. We evaluated the usefulness of the body mass index (BMI), prognostic nutrition index (PNI), and controlling nutritional status score (CONUT) for evaluating post-operative complication risk by examining the relationship between pre-operative nutritional status and the occurrence of post-operative complications such as surgical site infection (SSI) and remote infection (RI).

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1041

Research Article  |   Volume 3, Issue 1

Microwave/Radiofrequency (MW/RF) Radiation Exposure and Cancer Risk: Meta-Analysis of Accumulated Empirical Evidence

Iris Atzmon, Shai Linn, Elihu D Richter and Boris Portnov
Abstract

Scientific debate regarding the health effects of Microwave/Radiofrequency (MW/RF) radiation has continued for decades, but has risen sharply in recent years due to an explosion in wireless technology. Several studies of the health effects of MW/RF radiation were published in recent years, but their results have not been analyzed to date using meta-analysis tools.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1040

Research Article  |   Volume 3, Issue 1

Microwave/Radiofrequency (MW/RF) Radiation Exposure and Cancer Risk: A Meta-analysis of Time-related Trends in the Accumulated Empirical Evidence

Iris Atzmon, Boris Portnov, Shai Linn and Elihu D Richter
Abstract

Scientific debate regarding health effects from MW/RF radiation has increased considerably in recent years. In the early 1980's much of the evidence concerning the health effects of MW/RF radiation came from occupational studies, however, in the 1990's and the 2000's, environmental studies became more dominant. This resulted from an increase in public awareness about exposure to MW/RF radiation.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1039

Original Article  |   Volume 3, Issue 1

Multimodal Treatment of Breast Cancer Liver Metastases Based on Hepatic Resection and Microwave Coagulo-Necrotic Therapy (MCN)

Yuko Takami, Susumu Eguchi, Masaki Tateishi, Tomoki Ryu, Kazuhiro Mikagi, Yoshiyuki Wada and Hideki Saitsu
Abstract

Background: Generally it is rare to select surgery for treating breast cancer liver metastases (BCLM), but we have carried out aggressively surgical treatment to BCLM. Especially as a part of treatment strategies, we have used intraoperative loco-regional microwave ablation, named microwave coagulo-necrotic therapy (MCN). In this study, we investigate whether or not surgical treatment, combining hepatic resection and/or MCN, is useful for treating BCLM. Methods: Between 1994 and 2014, 33 patients with BCLM were surgically treated at National Hospital Organization Kyushu Medical Center by means of resection and/or MCN, followed by chemotherapy and/or endocrine therapy. The overall survival (OS) and disease-free survival (DFS) rates were determined.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1038

Research Article  |   Volume 3, Issue 1

Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer

Renty B. Franklin, Jing Zou, Yao Zheng, Michael J. Naslund, Leslie C. Costello
Abstract

Prostate cancer remains the second leading cause of cancer deaths in males. This is mainly due to the absence of an available efficacious chemotherapy despite decades of research in pursuit of effective treatment approaches. A plausible target for the treatment is the established clinical relationship that the zinc levels in the malignant cells are markedly decreased compared to the normal epithelium in virtually all cases of prostate cancer, and at all stages malignancy. The decrease in zinc results from the downregulation of the functional zinc uptake transporter, ZIP1; which occurs during early development of prostate malignancy.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/3/1/1037