Laparoscopic-Assisted Surgery for Malignant Fibrous Histiocytoma Originating from the Descending Colon: A Case Report and Literature Review
Keiji Matsuda, Takahiro Yagi, Mitsuo Tsukamoto, Yoshihisa Fukushima, Takuya Akahane, Ryu Shimada, Atsushi Horiuchi, Keisuke Nakamura, Takeshi Tsuchiya, Tamuro Hayama, Junko Tamura, Hisae Iinuma, Shoichi Fujii, Keijiro Nozawa, Takuo Tokairin, Yuko Sasajima, Fukuo Kondo and Yojiro Hashiguchi
Article Type: Case Report | First Published: August 30, 2015
Primary malignant fibrous histiocytoma (MFH) localized in the large intestine is extremely rare. We report a first case of MFH in colon that underwent a laparoscopy-assisted colectomy. A 74-year-old female had a 3-month history of blood stool. Barium enema study showed protrusion in the descending colon. Colonoscopy revealed submucosal tumor-like lesion with central ulceration. A biopsy was obtained and the pathological report was that MFH was suspected. Laparoscopic-assisted left hemicolectomy ...
A Randomized Double Blinded Study of Ganoderma Lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer
Prapaporn Suprasert, Chatchawann Apichartpiyakul, Choompone Sakonwasun, Pimonphan Nitisuwanraksa and Rochana Phuackchantuck
Article Type: Research Article | First Published: August 28, 2015
Lingzhi is a widely used anti-cancer herbal medicine in Asian countries with limited knowledge of the efficacy especially in gynecologic cancer patients. This study was conducted to compare the efficacy of Lingzhi in the forms of water extract type and spore type with a placebo control in a salvage setting of gynecologic cancer treatment. Sixty gynecologic cancer patients who failed at least two regimens of chemotherapy were randomly divided equally to ingest 6000 mg/day of Lingzhi in form of wa...
Reducing Sample Sizes in Phase II Trials based on Exact Binomial Tests by Shifting Design Parameters
Dirk Klingbiel, Qiyu Li and Martin Bigler
Article Type: Research Article | First Published: August 20, 2015
Currently, a large number of new anticancer agents is accompanied by constrained resources, requiring prioritization. In addition, emerging molecular subtypes subdivide common cancer entities into rare diseases, making it harder to conduct phase II trials as a crucial step in drug development and therapy optimization. We extend a recent work by Khan et al. on the design of phase II clinical trial based on exact binomial tests....
Screening for the Polyomaviruses BKV, JCV and SV40 in Pediatric Malignancies
Karin Kosulin, Alexander Zimmerhack, Johannes A. Hainfellner, Christine Haberler, Gabriele Amann, Susanna Lang and Thomas Lion
Article Type: Research Article | First Published: July 31, 2015
Different studies suggested an oncogenic potential of the polyomaviruses JC virus, BK virus and simian virus 40, particularly in brain tumors and neuroblastoma, which belong to the most frequent malignancies in children. However, currently available data are controversial, possibly due to the different regional prevalence of the viruses and the detection techniques used. To elucidate the presence of these polyomaviruses in the indicated tumor entities and in childhood cancer in general, we have ...
A Simple Two-Stage PCR Method for Quality Amplification of Degenerate DNA
Ebili Henry O, Ham-Karim Hersh Abdul and Ilyas Mohammad
Article Type: Original Article | First Published: July 06, 2015
Formalin-fixed, paraffin-embedded (FFPE) tissue banks are invaluable to cancer genetics and biomarker discovery. However, FFPE tissue-derived DNA is degenerate. As such, any PCR technique which will give adequate amplification of such DNA to enable downstream applications is important to the characterization of genetic biomarkers and to personalized medicine. The aim of this article is to describe a two-stage PCR method which efficiently amplifies degenerate FFPE tissue-derived DNA. Amplicon enr...