Reference Intervals in Malaysia: A Performance Evaluation and Comparison of Haematological Parameters between Sysmex XE-5000 and XN-3000
Siew Lian CHONG, Asral Wirda AHMAD ASNAWI, Kian Boon LAW, Roszymah HAMZAH and Sen Mui TAN
Article Type: Brief Report | First Published: December 23, 2021
The Sysmex XN-3000 is a new automated haematology analyser designed to improve the accuracy of cell counts and the specificity of the flagging events of unusual parameters. By comparing the previous full blood count (FBC) reference intervals in Malaysia for Sysmex XE- 5000, we determined a reference interval for all parameters measured by the Sysmex XN-3000 for the Malaysian population. Through the voluntary recruitment of 397 adults ages 18-45 years, both genders, and the three main ethnic grou...
Coagulation Abnormalities in Pregnant Women with COVID-19
Vladimir Y Khryshchanovich, MD and Natalia Y Skobeleva, BS
Article Type: Letter to Editorial | First Published: December 18, 2021
Late pregnancy and the early postpartum period are characterized by the so-called physiological hypercoagulation: The concentration of blood clotting factors I, II, VIII, IX, X increases twice, the functional activity of platelets increases, and the fibrinolytic activity of serum decreases. On the one hand, the prothrombotic status reduces the risk of massive blood loss in childbirth, and on the other - creates prerequisites for the development of venous thromboembolism. In the context of assess...
Echelons of Some Haemoparasites among Blood Donors in Port Harcourt, Rivers State, Nigeria
Evelyn Mgbeoma Eze, Serekara Gideon Christian, Ransom Baribefii Jacob, Barinaaziga Sunday Mbeera, Beatrice Wobiarueri Moore-Igwe and Angela Tornubari Mbari
Article Type: Original Article | First Published: December 04, 2021
Although the therapeutic application of whole blood and blood components can be life-saving, inadequate screening of these products could pose life-threatening problems to the recipient. The aim of this study was to determine the echelons of some haemoparasites (malaria parasite, microfilaria and babesia species) among blood donors in Port Harcourt, Rivers State, Nigeria as well as quantifying their densities. A total of one hundred (100) prospective blood donors from the participating blood ban...
Assessment of the Usefulness of Red Cell Indices as a Screening Tool in Haemoglobin E Trait: A Cross Sectional Study
DMHMK Dassanayake, VCP Gunawardena and SB Athauda
Article Type: Original Article | First Published: September 29, 2021
HamoglobinE (HbE) is the second commonest structural haemoglobin variant and results from mutation in the β globin gene causing substitution of glutamic acid for lysine at position 26 of the β globin chain. When coinherited with β Thalassemia it becomes a major health burden. To assess the effectiveness of red cell parameters as a screening tool to identify haemoglobin E traits and to develop a score using red cell parameters which help to identify Haemoglobin E traits in population screening...
Diagnostic Value of miR-26b in Schizophrenia
Ling-ming Kong, Xiao-li Zhu and Li-yi Zhang
Article Type: Original Article | First Published: September 22, 2021
This study aimed to investigate the diagnostic value of peripheral microRNA (miRNA) expression in schizophrenia (SZ). By using an Affymetrix array to identify differentially expressed miRNAs in SZ patients; quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to verify identified microRNA and test major depressive disorder (MDD), generalized anxiety disorder (GAD) and mental retardation (MD) related microRNAs for comparison. The expression levels of miR-1972...
SMYD2 in Leukemia: An Update
Article Type: Mini-Review Article | First Published: August 30, 2021
SMYD2 is one of the five members (SMYD1-5) of the Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family and is it known to methylate histone and non-histone substrates. By methylating a wide range of targets, SMYD2 acts as an oncogene in most cancer types. In this review I will comment on the last publications related to the role of SMYD2 in leukemia and I will refer to more extensive reviews if the reader aims to have a b...
Hypogonadotropic Hypogonadism in a Female Patient with Thalassemia Major
Richmond R Gomes
Article Type: Review Article | First Published: August 28, 2021
Thalassemia refers to a group of inherited diseases characterized by decreased or absent synthesis of normal globin chains. The direct consequence is an imbalance of the alpha and beta globin chain synthesis that results in anemia from ineffective erythropoiesis and hemolysis. The term thalassemia major refers to the severe form that is often associated with life-long transfusion dependent anemia. Hypogonadism is the most frequently reported endocrine complication, affecting 70-80% of thalassemi...