International Journal of

Blood Research and DisordersISSN: 2469-5696


 Open Access DOI:10.23937/2469-5696/1410046

First Observation of Two TMPRSS6 Gene Mutations (G603R and K636AFSX17) in Turkish Population

Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar

Article Type: Case Report | First Published: December 20, 2019

Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively reg...

 Open Access DOI:10.23937/2469-5696/1410045

Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria

Oyelese AT, Salawu L, Adejuyigbe EA and Olasanmi O

Article Type: Review Article | First Published: December 12, 2019

Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its associatio...

 Open Access DOI:10.23937/2469-5696/1410044

Repeat Ultrasonographic Examinations Reveal Accessory Spleen in a Case with Relapse ITP

Ahmet Sarici, Ayshe Slocum, Hilal Er Ulubaba, Mehmet Hanifi Kandemir, Mehmet Ali Erkurt, Emin Kaya and Irfan Kuku

Article Type: Original Article | First Published: August 09, 2019

The aim of treatment in patients with primary immune thrombocytopenia (ITP) is to obtain a safe platelet count to prevent clinically significant bleeding (major bleeding) rather than normalizing the platelet count. In light of this information, treatment indications for newly diagnosed ITP patients include, I) Thrombocyte counts below 30,000/microL and II) Platelet counts above 30,000/microL in correlation with clinically significant bleeding. Corticosteroids make-up the first-line treatment of ...

 Open Access DOI:10.23937/2469-5696/1410043

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Hakan Kaya

Article Type: Research Article | First Published: July 17, 2019

Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 201...

 Open Access DOI:10.23937/2469-5696/1410042

Geriatric Presentation of Hyperleukocytosis in Setting of B-Cell Acute Lymphoblastic Leukemia, Border-Zone Ischemic Stroke and Endocarditis

Christian Cajavilca, Tina Yaqing Cai Lam, Alexandra Vaio Sykes, Shannon Wheeler and Rajan R Gadhia

Article Type: Case Report | First Published: July 04, 2019

81-year-old female presented to an outside emergency room with subacute onset of left facial weakness and right hemiparesis for 12 hours. A non-contrast CT scan of the head and CTA head and neck showed no acute findings. Laboratory results were remarkable for a leukocyte count of 245.75 k/uL. She was diagnosed with acute leukemia and transferred to a comprehensive stroke center where she was treated with leukapheresis and hydroxyurea. The patients focal deficits somewhat improved, but in the fol...

 Open Access DOI:10.23937/2469-5696/1410041

Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling

Michael Tarasev, Marina Muchnik and Sumita Chakraborty

Article Type: Original Article | First Published: June 27, 2019

While in circulation, red blood cells (RBC) need to elastically undergo large deformations without lysing, an ability that may be compromised by cell membrane damage. Such can be tested in vitro by subjecting an RBC sample to external mechanical stress, e.g. through bead milling or oscillation of an object in a sample. In addition to controlling frequency and duration of oscillations, this approach can be further tailored by bead selection/design....

 Open Access DOI:10.23937/2469-5696/1410040

ABO Blood Group: Its Relationship with Anthropometric Parameters Among Young Adult Nigerians of Yoruba Ethnicity

Asafa MA, Ogunlade O, Bolarinwa RA, Bisiriyu LA and Asafa ST

Article Type: Research Article | First Published: June 17, 2019

It had been established that ABO blood group system associated with some diseases or disorders. The objective of this study was to determine the effect of ABO blood group on anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB...

 Open Access DOI:10.23937/2469-5696/1410039

Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient

Haruko Tashiro MD, PhD, Yasutoshi Oshima, Ritsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naohisa Matsunaga, Yoshinao Kikuchi and Naoki Shirafuji

Article Type: Case Report | First Published: May 16, 2019

Survival rates for patients with severe aplastic anemia have greatly improved with the development of better supportive care including transfusion strategies and the availability of anti-fungal agents. However, invasive fungal infection remains the main cause of death and increases mortality in severe aplastic anemia patients. Among invasive fungal infections, mucormycosis is one of the fatal diseases in immunocompromised patients. We report the case of a 72-year-old man with severe aplastic ane...

 Open Access DOI:10.23937/2469-5696/1410038

MEK1/2 as a Therapeutic Target in Sickle Cell Disease

Rahima Zennadi

Article Type: Short review | First Published: April 04, 2019

Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...

 Open Access DOI:10.23937/2469-5696/1410037

Is an Additional Dose of Intravenous Ferric Carboxymaltose Useful in the Treatment of Iron Deficiency Anemia?

Sinem Namdaroglu, MD and Gizem Yıldırım

Article Type: Research Article | First Published: March 06, 2019

Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....

 Open Access DOI:10.23937/2469-5696/1410036

Diffuse Large B-Cell Lymphoma during Complete Remission of Acute Myeloid Leukemia (M4Eo) Exhibiting Immunoglobulin Heavy Chain Gene Rearrangement and Inv(16)

Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki

Article Type: Case Report | First Published: January 25, 2019

In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...

 Open Access DOI:10.23937/2469-5696/1410035

Utilizing Extended Red Blood Cell Parameters to Distinguish Iron-Deficient Erythropoiesis - Related Disorders in Malaysian Female Population

Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar

Article Type: Research Article | First Published: January 20, 2019

The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...

Volume 6
Issue 1