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International Journal of

Blood Research and DisordersISSN: 2469-5696

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 Open Access DOI:10.23937/2469-5696/1410028

Zika Induced Meningoencephalitis in a Ruxolitinib Treated Patient with Secondary Myelofibrosis

Ahmad Al Ghoche, Jean Pegliasco, Jessica Anne-Marie-Sainte, Julien Cuziat, Lucas Meyer, Fatiha Najioullah, Jean Côme Meniane and Samy Chraïbi

Article Type: Case Report | First Published: October 28, 2017

We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed....

 Open Access DOI:10.23937/2469-5696/1410027

Interstitial Deletion of Chromosome 9q in Therapy-Related Acute Promyelocytic Leukemia with Pathognomonic t(15;17) in a Patient Exposed to Radioactive Iodine

Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros

Article Type: Case Report | First Published: September 29, 2017

The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....

 Open Access DOI:10.23937/2469-5696/1410026

Bone Marrow Necrosis: An Unusual Misdiagnosed Serious Complication

Georges El Hachem

Article Type: Literature Review | First Published: July 31, 2017

Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease....

 Open Access DOI:10.23937/2469-5696/1410025

Polycomb Proteins in Hematopoiesis and Hematologic Malignancie

Jie Li

Article Type: Review Article | First Published: March 20, 2017

In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....

Volume 4
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