International Journal of

Allergy MedicationsISSN: 2572-3308

Archive

 Open Access DOI:10.23937/2572-3308.1510010

Monitoring for Adverse Events Post Marketing Approval of a Drug

Karl E Peace and Macaulay Okwuokenye

Article Type: Short Review | First Published: November 05, 2015

This brief communication provides information to those developing monitoring plans for serious adverse events (SAE's) following regulatory approval of a new drug. In addition, we (1) illustrate how many patients would need to be treated in order to have high confidence of seeing at least 1 pre-specified SAE, (2) show that absence of proof of a SAE is not proof of absence of that SAE, and (3) identify statistical methodology that could be used for formal statistical monitoring of SAE's....

 Open Access DOI:10.23937/2572-3308.1510009

A New Strategy for Mitigation of the Allergenic Activity of Ovomucoid in Hen Eggs and Beta-Lactoglobulin in Cow Milk

Jun Kido, Natsuko Nishi, Sachiko Misumi and Tomoaki Matsumoto

Article Type: Short Review | First Published: November 02, 2015

Recently, public interest in food allergies has been increasing because of increasing prevalence of these allergies among children. In Japan, hen egg and cow milk allergies account for nearly 50% of all cases of childhood food allergies. Patients with hen egg and cow milk allergies should avoid these foods and products that contain them until they have outgrown their allergies. However, regarding nutrition, quality of diet, and hyposensitization, it is significantly important for these patients ...

 Open Access DOI:10.23937/2572-3308.1510008

Environmental Factors Urging the Development of Atopic Diseases in 75 Children

Arnaldo Cantani

Article Type: Review Article | First Published: September 11, 2015

Atopy can interfere with a child's life at any age level, with varying severity. Intractable diarrhea due to CM allergy (CMA) and AD are the most frequent in infants, where the clinical manifestations are more severe than in older children. Respiratory allergy and bronchial asthma can be serious illnesses in younger as well as in older children....

 Open Access DOI:10.23937/2572-3308.1510007

Delayed Hypersensitivity to Lidocaine Cross-Reactivity with Others Amide-Type Anesthetics

Juan Luis Estrada-Rodriguez, Angel Rodriguez-Paredes, Margarita Latasa and Jose Luis Perez-Laiz

Article Type: Case Report | First Published: September 04, 2015

We notice a patient consulting for several eczema episodes related to topical ointments containing lidocaine. Study was made, and amyde-type local anesthetics cross-reactivity in this patient, is reported. Usefulness of different diagnostic tests is also discussed....

 Open Access DOI:10.23937/2572-3308.1510006

Epinephrine Auto-Injectors

Ozlem Yilmaz Ozbek

Article Type: Short Review | First Published: September 04, 2015

Anaphylaxis is a systemic, life-threatening reaction and immediate treatment is essential. The reaction can be fatal even with epinephrine injection. Epinephrine auto-injectors have been used in the emergency treatment of anaphylaxis since the 1980s. In this review, indications for the prescription, types, administration, and the problems with the use of epinephrine auto-injectors are discussed. The importance of patient and caregiver education is highlighted....

 Open Access DOI:10.23937/2572-3308.1510005

Identify the Inhibitors ... and Activate Them

Michael Huber

Article Type: Editorial | First Published: July 22, 2015

In contrast to positively acting signaling elements/ pathways that are typically targeted by small-molecule inhibitors, attenuating/ inhibiting signaling proteins would have to be pharmacologically activated to accomplish suppression of cellular pro-inflammatory reactions. Indeed, the meroterpenoid pelorol identified in sponge extract was demonstrated to efficiently activate SHIP1 phosphatase function and structural analogs thereof exhibited even greater activity in cell and mouse models of infl...

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