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International Archives of

Cardiovascular DiseasesISSN: 2643-3966

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 Open Access DOI:10.23937/iacvd-2017/1710013

Clinical Significance and Applications of D-Ribose in Cardiovascular Disease

Melike Bayram, David Perkowski, JA St Cyr and William T Abraham

Article Type: Review Article | First Published: December 15, 2018

Cardiovascular disease is the leading cause of deaths worldwide. Myocardial ischemia, a common etiological factor in cardiovascular disease, lowers cellular high-energy phosphate levels, i.e. adenosine triphosphate (ATP), with an accompanying impairment in myocardial function. Furthermore, scientists have argued for the importance of ATP levels in supporting both systolic and diastolic function in heart failure. The magnitude of ischemic heart disease and congestive heart failure is generally we...

 Open Access DOI:10.23937/iacvd-2017/1710012

Why Atherothrombosis is in Principle a Hematologic Disease: The Effect of Disorders and Drugs which Affect Thrombosis on the Development of Atherosclerotic Plaques

Gregory D Sloop, Gheorghe Pop, Joseph J Weidman and John A St Cyr

Article Type: Research Article | First Published: December 01, 2018

The authors hypothesize that thrombosis causes both the complications of atherosclerosis as well as the underlying lesion, the atherosclerotic plaque. Atherosclerotic plaques develop from the organization of mural thrombi. In this process, circulating progenitor cells trapped within the thrombus differentiate into myofibroblasts which synthesize collagen, and endothelial cells which form granulation tissue. Eventually, all or most of the thrombus is replaced by collagen. Thus, conditions and dru...

 Open Access DOI:10.23937/iacvd-2017/1710011

Sex-Related Risk of Myocardial Infarction: Insights from Path Analysis

Mohammad Reza Dayer, Vahideh-Sadat Nazemi, Mohammad Saaid Dayer and Sayed Mohammad Reza Alavi

Article Type: Research Article | First Published: November 19, 2018

Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic ...

 Open Access DOI:10.23937/iacvd-2017/1710010

Takotsubo Cardiomyopathy Pathophysiology May Also Affect the Gut

Paolo Angelini

Article Type: Case Report | First Published: November 19, 2018

In this report, we describe a patient who presented with transient acute abdomen before the onset of an acute myocardial ischemic event. Chest pain, dyspnea, and hypotension requiring vasopressors developed 2 days after the patient presented with paralytic ileus. Transient left-bundle-branch block and mildly elevated troponin and brain-natriuretic peptide levels occurred. Echocardiography and left ventricular angiography revealed extensive periapical akinesia and a left ventricular ejection frac...

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