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Mini Review  |   Volume 3, Issue 1

Novel Concepts for Clinical Pharmacology from "Calcium Paradox" due to Neuronal Interaction between Signalling Pathways Mediated by Ca2+ and cAMP: from 1975 to 2017

Leandro Bueno Bergantin and Afonso Caricati-Neto

The solution for the so-called "calcium paradox" has been revealed 4 years ago, when we demonstrated the involvement of the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling interaction) in this enigma.

PDF   |    Full Text | DOI: 10.23937/2572-3987.1510013

Review Article  |   Volume 3, Issue 1

Dietary Flavonoids and Colorectal Cancer: Evidence from Epidemiological Studies

Katrin Sak

Identification of dietary agents related to colorectal carcinogenesis is of high importance to decrease the global burden of this severe disorder. As flavonoids abundantly present in plant-based food items are suggested to exert various anticancer activities in numerous experimental models, evidence from epidemiological studies about association.

PDF   |    Full Text | DOI: 10.23937/2572-3987.1510012

Case Report  |   Volume 3, Issue 1

Prolonged Coagulopathy Following Rattlesnake Envenomation Responsive to Antivenom: A Case Report

Megan Z Roberts, Brian P McKinzie, Stuart M Leon, Stephen A Fann and Nicole M Bohm

Venom-specific immunoglobulin G fragments are used for the management of patients with North American crotalid envenomation. In this case, ongoing coagulopathy and clinically significant sequelae required a protracted course of antivenom therapy in a patient experiencing severe rattlesnake envenomation.

PDF   |    Full Text | DOI: 10.23937/2572-3987.1510011

Review Article  |   Volume 3, Issue 1

Pharmaceutical Characterization and Detection Using Surface-Enhanced Raman Scattering

Tawfik A Saleh

Surface-enhanced Raman scattering (SERS) is a surface sensitive method that results in the enhancement of Raman scattering by molecules adsorbed on rough metal surfaces. The enhancement factor can be as much as 107 -1015, which allows the technique to be sensitive enough to detect single molecules.

PDF   |    Full Text | DOI: 10.23937/2572-3987.1510010

Review Article  |   Volume 3, Issue 1

Levothyroxine for Hypothyroidism: Current Status of Biowaiver and Bioequivalence Studies

Nunez-Guzman NA, Munoz-Ibarra AI, Ruiz-Molina D, Figueroa-Nunez B and Garcia-Perez ME

Hypothyroidism is a common disease that needs to be closely treated, in order to reduce adverse symptoms and pathophysiological effects. For thyroid hormone replacement is preferred a therapy with a synthetic form of thyroxine (levothyroxine), a drug recognized by its Narrow Therapeutic Index. Generic levothyroxine can be an economic alternative for Hypothyroidism treatment.

PDF   |    Full Text | DOI: 10.23937/2572-3987.1510009

Volume 3
Issue 1