International Archives of

Clinical PharmacologyISSN: 2572-3987


Case Report Open Access

Increase in Carbamazepine Serum Levels in Patient Treated with Voriconazole

Alberto Sanchez-Romero, Ana Valladolid-Walsh, Rafael Garcia-Delgado and Esperanza Lopez-Rubio
Int Arch Clin Pharmacol Volume 2, Issue 1

Abstract: The addition of voriconazole to chronic treatment with carbamazepine 400 mg twice a day was associated with increased carbamazepine serum levels (14.1 mg/l) and serum concentration dose ratios. Three days after the voriconazole was started, this ratio doubled its value to 1. Carbamazepine concentration as well as serum concentration dose ratio gradually decreased after treatment with voriconazole was discontinued, suggesting a probable interaction between the two drugs, according to the drug interaction probability scale.

PDF   | Full Text   | XML   | PubReader   DOI: 10.23937/2572-3987.1510008

Review Article Open Access

Insight from 'Calcium Paradox' due to Ca2+ / cAMP Interaction: Novel Pharmacological Strategies for the Treatment of Depression

Leandro Bueno Bergantin and Afonso Caricati-Neto
Int Arch Clin Pharmacol Volume 2, Issue 1

Abstract: Depression is a psychiatric disease resulting mainly by dysfunction of monoaminergic neurotransmission in central nervous system. Depression is a severe global illness, becoming more and more common each decade. Because of specific symptoms, it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than one-third of patients do not respond to the current therapy.

PDF   | Full Text   | XML   | PubReader   DOI: 10.23937/2572-3987.1510007

Case Report Open Access

Unacceptable Intravenous Administration of Chloral Hydrate Oral Solution

Turgay Cokyaman, Omer Ertugrul, Haydar Ali Tasdemir and Ayhan Dagdemir
Int Arch Clin Pharmacol Volume 2, Issue 1

Abstract: Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After oral or rectal administration, central nervous system (CNS) and respiratory depression, cardiac arrhythmia and gastric irritation are known as classical adverse effects. Although the adverse effects developing after enteral usage are well known, there are limited data in literature about the misuse of chloral hydrate oral solution intravenously and the adverse effects that may be seen after this usage. In this article, it is intended that chloral hydrate oral solution has been mistakenly administered intravenously and it is a fact that there isn't any seen complication except localized skin erythema.

PDF   | Full Text   | XML   | PubReader   DOI: 10.23937/2572-3987.1510006

Original Article Open Access

Mass Dose Effects of Carfentanil and Raclopride on Venous Plasma Cortisol and Prolactin after Tobacco Smoking during PET Scanning

Edward F Domino, Lisong Ni and Mika Hirasawa-Fujita
Int Arch Clin Pharmacol Volume 2, Issue 1

Abstract: Peak cortisol levels after average nicotine (avnic) tobacco smoking were decreased with greater carfentanil doses (p = 0.03). The change in plasma cortisol levels after avnic smoking compared to before avnic smoking was also decreased with greater carfentanil doses (p = 0.003). Unexpectedly the changes in cortisol levels after denicitinized (denic) tobacco smoking compared to before denic smoking were increased with greater carfentanil doses (p = 0.04). No dose effects of raclopride were found on cortisol levels. Peak prolactin levels after avnic smoking were increased with greater raclopride doses (p = 0.003).

PDF   | Full Text  DOI: 10.23937/2572-3987.1510005

Case Report Open Access

Case Report: Addition of Naltrexone and Bupropion to Lorcaserin to Manage Olanzapine-induced Weight Gain

Kevin Bera, Eric Tran and Charles T. Nguyen
Int Arch Clin Pharmacol Volume 2, Issue 1

Abstract: Antipsychotic medications, both typical and atypical, share the potential side effect of weight gain with atypical agents carrying a greater risk. Atypical antipsychotics, such as clozapine and olanzapine, which antagonize the 5-hydroxytryptamine (serotonin) subtype 5-HT2C receptor, have been associated with a higher likelihood to induce weight gain.

PDF   | Full Text  DOI: 10.23937/2572-3987.1510004

Volume 2
Issue 1