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International Archives of

Clinical PharmacologyISSN: 2572-3987

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 Open Access DOI:10.23937/2572-3987.1510008

Increase in Carbamazepine Serum Levels in Patient Treated with Voriconazole

Alberto Sanchez-Romero, Ana Valladolid-Walsh, Rafael Garcia-Delgado and Esperanza Lopez-Rubio

Article Type: Case Report | First Published: December 05, 2016

The addition of voriconazole to chronic treatment with carbamazepine 400 mg twice a day was associated with increased carbamazepine serum levels (14.1 mg/l) and serum concentration dose ratios. Three days after the voriconazole was started, this ratio doubled its value to 1. Carbamazepine concentration as well as serum concentration dose ratio gradually decreased after treatment with voriconazole was discontinued, suggesting a probable interaction between the two drugs, according to the drug int...

 Open Access DOI:10.23937/2572-3987.1510007

Insight from 'Calcium Paradox' due to Ca2+ / cAMP Interaction: Novel Pharmacological Strategies for the Treatment of Depression

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Review Article | First Published: September 12, 2016

Depression is a psychiatric disease resulting mainly by dysfunction of monoaminergic neurotransmission in central nervous system. Depression is a severe global illness, becoming more and more common each decade. Because of specific symptoms, it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than one-third of patients do not respond to the current therapy....

 Open Access DOI:10.23937/2572-3987.1510006

Unacceptable Intravenous Administration of Chloral Hydrate Oral Solution

Turgay Cokyaman, Omer Ertugrul, Haydar Ali Tasdemir and Ayhan Dagdemir

Article Type: Case Report | First Published: August 04, 2016

Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After oral or rectal administration, central nervous system (CNS) and respiratory depression, cardiac arrhythmia and gastric irritation are known as classical adverse effects. Although the adverse effects developing after enteral usage are well known, there are limited data in literature about the misuse of chloral hydrate oral solution intravenously and the adverse effects that may be seen after this usa...

 Open Access DOI:10.23937/2572-3987.1510005

Mass Dose Effects of Carfentanil and Raclopride on Venous Plasma Cortisol and Prolactin after Tobacco Smoking during PET Scanning

Edward F Domino, Lisong Ni and Mika Hirasawa-Fujita

Article Type: Original Article | First Published: May 09, 2016

Peak cortisol levels after average nicotine (avnic) tobacco smoking were decreased with greater carfentanil doses (p = 0.03). The change in plasma cortisol levels after avnic smoking compared to before avnic smoking was also decreased with greater carfentanil doses (p = 0.003). Unexpectedly the changes in cortisol levels after denicitinized (denic) tobacco smoking compared to before denic smoking were increased with greater carfentanil doses (p = 0.04). No dose effects of raclopride were found o...

 Open Access DOI:10.23937/2572-3987.1510004

Case Report: Addition of Naltrexone and Bupropion to Lorcaserin to Manage Olanzapine-induced Weight Gain

Kevin Bera, Eric Tran and Charles T. Nguyen

Article Type: Case Report | First Published: January 25, 2016

Antipsychotic medications, both typical and atypical, share the potential side effect of weight gain with atypical agents carrying a greater risk. Atypical antipsychotics, such as clozapine and olanzapine, which antagonize the 5-hydroxytryptamine (serotonin) subtype 5-HT2C receptor, have been associated with a higher likelihood to induce weight gain....

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