International Archives of

Clinical PharmacologyISSN: 2572-3987


Review Article Open Access

A Review: Are All Inhaled Fibres, Such as Asbestos, Toxic?

Sumayah Abdul-Jabbar and Luigi G Martini
Int Arch Clin Pharmacol Volume 1, Issue 1

Abstract: Exposure to asbestos is well known to have a causal relationship with the development of lung cancer. In order to understand the mechanism of this toxicity an extensive review was undertaken. Findings were able to show that the morphology of the asbestos (which is fibrous) has a marked correlation with its toxicity. It is this morphology that mutually contributes to enhanced aerodynamic properties making asbestos ideal for deposition in the lungs as well as giving it mutagenic properties. Therefore, it is inappropriate to ignore the intrinsic property of fires, especially due to an increase in the amount of synthetic fires used commercially including the pharmaceutical industry.

PDF   | Full Text  DOI: 10.23937/2572-3987.1510003

Research Article Open Access

Evaluation of Empirical Antibiotic Therapy for the Treatment of Community-Acquired Urinary Tract Infections (CA-UTI)

Joao Pedro Aguiar, Filipa Alves da Costa and Patricia Cavaco Silva
Int Arch Clin Pharmacol Volume 1, Issue 1

Abstract: Objectives: To characterize the pattern of indication of antibiotic regimens for CA-UTI; to evaluate the adequacy of antibiotic empirical therapy in CA-UTI and the resistance profile of the bacterial isolates. Methods: An observational study was conducted, where the prevalence and resistance profiles of the microorganisms involved and the pattern of antibiotic indication were investigated through a cross-sectional approach. Patients presenting with UTI symptomatology and antibiotic indication were recruited through pharmacies in the Lisbon area. Upon inclusion, participants collected a urine sample and responded to a questionnaire characterizing the indication pattern and symptomatology presented.

PDF   | Full Text  DOI: 10.23937/2572-3987.1510002

Review Article Open Access

Amitriptyline Therapy in Chronic Pain

Min Su, Liang Liang and Shengyuan Yu
Int Arch Clin Pharmacol Volume 1, Issue 1

Abstract: Rodent evidence has confirmed the analgesic effect of tricyclic antidepressants in the treatment of chronic pain, which amitriptyline is rigorously verified. The analgesic effect of amitriptyline, whose mechanisms are complex and unclear, is different from its antidepressant effect. This article reviewed the mechanisms behind amitriptyline's analgesic properties to further understanding of this drug. Additionally, this article reviewed the clinical evidence of the effectiveness of amitriptyline therapy in treatment of chronic pain to offer guidance for future clinical practice.

PDF   | Full Text  DOI: 10.23937/2572-3987.1510001

Volume 1
Issue 1