Asthma and allergic diseases typically start in childhood and are the most common chronic inflammatory diseases among children over the world. Therefore, understanding the mechanisms and advancing the treatment of these disorders are of high importance. The aim of this special issue is to provide a forum in which a number of original research, contemporary reviews and case reports can come together in order to update our readers on the major advances in the fields of asthma and allergies in children.
Dr. Haibin wang received his Ph.D. from Peking University Health Science Center, China in 1999, and completed his postdoctoral fellowship training in 2002 at Division of Allergy, Inflammation and Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School. He has been remaining on the faculty of the same Division at Harvard for 12 years. His research focuses on the immunoregulatory roles of eosinophils, including roles for eosinophils as antigen-presenting cells in regulating regional and systemic T cell responses in allergic diseases including asthma, and roles of eosinophil-secreted cytokines in directing T cell differentiation and in B cell priming and activation. He has authored/co-authored over 20 peer-reviewed publications in international journals, books and conference proceedings.
Yi Liu, MD, professor and chief physician, master tutor, China Medical University Hospital of Stomatology Mukden clinic director, graduated from China Medical University in 1988, gained PhD in 2004, at the Northeastern University postdoctoral station from 2004 to 2008, learning the technical training of Tweed fixed appliance in South Korea in1999 and 2006, training at Kobe University in 2001. Engaged in medical care, teaching, and research work of orthodontics from 1988 to date. Mainly engaged in the researches of the identification of pathogenic gene of familial permanent teeth deletion; the regulatory role of mTOR in the growth and proliferation of cells and oral neoplasms; the application of orthodontic treatment in oral medicine, surgery, prosthodontics and other disciplines the regulatory role of PI3K/Akt/mTOR signaling pathway in orthodontic teeth movements. Presided over ten provincial and municipal research projects and the research funding was nearly 100 million yuan. Have published more than 100 papers, including 13 SCI papers. Have gained four Liaoning Provincial Science and Technology Achievements, a total of eight awards of Liaoning Province Science and Technology Progress first, second, third prize and Shenyang Science and Technology Progress first, second, third prize. Have trained nearly thirty postgraduates.
Chronic Obstructive Pulmonary Disease (COPD) is an important cause of mortality, morbidity and health-care costs worldwide. It is a preventable and treatable condition characterized by progressive but not fully reversible airflow limitation. Patients with similar degree of airflow limitation differ in their clinical, radiological, functional presentation and response to therapy. Hence, the recent GOLD intiatives (Global strategy for the diagnosis, management and prevention of COPD) classify COPD patients based on multidimensional evaluation which includes assessment of severity of symptoms, risk of exacerbations along with the severity of the airflow limitation on spirometry measurements. Recent interest to identify clinically relevant phenotypes beyond the classic chronic bronchitis and emphysema subtypes will allow us for a better management strategy and thus better outcomes.
Rajapriya Manickam is a senior fellow physician in Pulmonary and Critical Care medicine at Westchester Medical Center/New York Medical College, USA. She has completed MD Internal Medicine Residency from Lincoln Medical center, Affiliated to Weill Medical College of Cornell University, NY. She is board certified in Internal Medicine and Pulmonary medicine. She also did her Internal Medicine residency at All India Institute of Medical Sciences (AIIMS), India and worked as an Assistant Professor at PSG Institute of Medical Sciences and Research before coming to USA. Her research interests are spirometry, lung cancer, COPD and clinical research in critical care medicine.
Annemarie Lee is a physiotherapist with clinical experience in chronic lung disease including pulmonary rehabilitation and airway clearance therapy. She completed her PhD in 2009, exploring the prevalence of gastro-oesophageal reflux disease in COPD and bronchiectasis, the presence of pulmonary aspiration and the effects of physiotherapy on gastro-oesophageal function. She has worked as a lecturer within the department of Physiotherapy, The University of Melbourne and is currently undertaking a postdoctoral research fellowship at West Park Healthcare Centre, Ontario, Canada. Her current research focus is on pain and its clinical implications in COPD and the role of adjunct therapy in pulmonary rehabilitation. Research interests are Bronchiectasis - airway clearance techniques and the role of exercise training, COPD - comorbidities of gastro-oesophageal reflux disease and pain, Pulmonary rehabilitation.
Despite an explosion of basic and clinical research over the past 2 decades, pulmonary hypertension remains a life-threatening disease in the world. Pulmonary hypertension is a complex, multidisciplinary disorder devastating the small pulmonary arteries and impairing right ventricular function. There remains an ongoing need for novel technologies and devices for diagnosis, monitoring, and treatment to improve its clinical outcomes.
Xiaojing Wu is an association professor of Cardiovascular Medicine at the Third Military Medical University in China. She got her MD and PhD degree in China, and had been a senior visiting scientist in the Center for Lung and Vascular Biology at UIC in the USA. Clinically she contributes to the treatment and prevention of vascular disease (in-patient and out-patient care). She is also a recipient of National Scientific foundation of China. Her main research interests cover the treatment and prevention of vascular remodeling and pulmonary embolism. She is especially interests in the study of pulmonary hypertension due to left heart diseases.
Lung cancer is a major cancer killer globally and will pose significant challenges in the coming decade because of the increase in air pollution. This special issue "Lung Cancer Challenges to the Future" will discuss any contemporary issues related to lung cancer including: Air pollution and lung cancer, Public health and epidemiology of lung cancer, Drug therapy for lung cancer, Radiotherapy for lung cancer Surgery for lung cancer, End of life palliative care related to lung cancer, Art pieces of poetry, prose, painting or photography about subjects important for lung cancer patients are also welcome separately or along with the scientific papers. This special issue attempts to bring together expert papers to offer a complete view of lung cancer, the related challenges and the treatment.
I am an independent researcher, not associated with any organization for my research. This work represents only my views. I believe to understand where and how our patients live, get sick and heal is an important part of medicine. And art illuminates science and medicine. I live in Lower East Side Manhattan that was once called the 5 points when Civil War broke out over a pair of shoes. Follow a boy's will (Robert Frost), people gather here where the hearts belong. So, people here take the time to hear the racks of stones and pebbles, and the petals dropping from rosemary, devil's claw, and cherry blossoms. Kindness hunts for self-seekers here in 5 points then, today and tomorrow. This is a place where many new immigrants like me take a rest and settle, and is a place that taught me being ernest. I have published a number of books and papers related to oncology, radiation oncology in particular, global epidemiology and public health of oncology of oncology and pollution. There will be a major challenge of cancer epidemic in the world related to environment and life style, especially in the Asia Pacific in the coming decade. Try to understand various challenges facing patients, cancer patients in particular, is the focus of my work. Think knowledge and kindness, the world will be a better place. @Lower Manhattan, 3.14.15.